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Dr. Syed Sultan Beevi

Overview :

As a dedicated researcher in the field of cancer biology, my passion lies in advancing the frontier of liquid biopsy techniques. Specifically, my current focus revolves around devising a novel approach tailored for glioma patients, a population facing particularly overwhelming challenges in diagnosis and treatment. I firmly believe that by perfecting our methods of detection and monitoring, we can significantly impact the trajectory of this disease for individuals and their families. Central to my approach is the isolation of exosomes from plasma—a sophisticated technique that holds immense promise in unlocking crucial insights into cancer biology. Exosomes offer a unique window into the molecular landscape of tumors, providing invaluable clues for early detection, drug response and potential disease recurrence.

Beside, I am utilizing the power of next-generation sequencing (NGS) to meticulously analyse the genetic signatures contained within these exosomes. NGS technology empowers us to sift through vast amounts of genetic data with unprecedented precision, enabling the identification of disease-specific variants that hold the key to more accurate diagnosis and prognosis.

Furthermore, I’m at the forefront of generating patient-derived tumor-associated macrophages (TAMs) to understand the immune suppressive nature of glioma. This model serves as a platform for developing novel immunotherapeutic drugs, further enhancing our ability to combat this devastating disease. Through these efforts, I am striving to equip clinicians with the tools they need to deliver more targeted and effective care, ultimately translating into better outcomes for those battling glioma and other forms of cancer.

Education :

  • Ph.D., Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, India.
  • M.Phil. Life Science, Manonmaniam Sundaranar University, Tirunelveli, India.
  • M.Sc., Clinical Biochemistry, University of Madras, Chennai, India.

Awards & Achievements :

  • 6 years of Post Doctoral Research Experience in Cancer and Stem Cell Biology.
  • Authored 24 original articles, 5 conference proceedings and One Monograph in Journals of International repute with an H-index of 10 (Citation Gadget).
  • Awarded highly competitive and prestigious CSIR-Fellowship, UGC-Kothari & DBT-RA Fellowship for conducting doctoral and postdoctoral research respectively.
  • Awarded Australian Endeavour Research Fellowship to conduct research at The University of Sydney as Visiting Scientist
  • Gold Medallist, Graduate & Masters at University of Madras.

Research Experience :

  • Scientist – Regenerative Medicine, KFRC, Secunderabad .(Present)
  • Visiting Scientist – Faculty of Pharmacy, University of Sydney, Australia.
  • Junior Consultant – Stem Cell Laboratory, Global Hospitals, Hyderabad.
  • Postdoctoral Fellow – Cancer Biology Group, CCMB, Hyderabad.

Publications :

  1. Beevi SS, Anbrasu K, Verma VK, Panchal NK, et al. Impact of Pim1 mutations on the survival outcomes of patients with breast cancer: Insights from a clinical study. Human Gene 2024; 201295
    2. Verma VK, Yadav R, Beevi SS, et al. Differential host responses to Covid-19: Unraveling the complexity. Diag MicroBiol Infect Dis 2024; 109: 116281
    3. Verma VK, Beevi SS, Nair RA, et al. MicroRNA signatures differentiate types, grades, and stages of breast invasive ductal carcinoma (IDC): miRNA-target interacting signaling pathway. Cell Commun Signal 2024; 22: 100.
    4. Beevi SS, Panigrahi MK, Verma VK et al. Patient-derived primary culture-based prognostic model to predict tumor recurrence in patients with glioma. Adv Bio Sci Tech 2024; 6: 8 – 19.
    5. Beevi SS, Verma VK. U18666A-induced cholesterol accumulation decreases tumor-derived exosomes load and modulate malignant transformation. Mol Can Ther 2023; 22: 12
    6. Beevi SS, Anbrasu K, Kannepalli KK et al. Impact of promoter region mutations of Pim-1 on c-Myc expression as well as survival in patients with breast cancer. J Med Sci Res 2023; 11: 30 – 33.
    7. Chowdary R, Pillarisetti RP, Verma VK, Korabathina R, Beevi SS. Prognostic significance of systemic cholesterol profile in patients with breast cancer. Can Res J 2022; 10: 30 – 33.
    8. Jose J, Hoque M, Engel J, Beevi SS et al. Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions. Sci Rep 2022: 12: 596.
    9. Beevi SS, Yadav R, Verma VK, et al. DNMT3A co-mutation with SF3B1, ASXL1 and TET2 in Indian patients with myelodysplastic syndrome (MDS). Biochem Mol Bio 2022; 7: 1 – 5.
    10. Panchal NK, Bhale A, Verma VK, Beevi SS. Computational and molecular dynamics simulation approach to analyze the impact of XPD gene mutation on protein stability and function. Mol Simul 2020; 46: 1200 – 1219.
    11. Nair RA, Verma VK, Beevi SS, Rawoof A et al. MicroRNA signatures in blood or bone marrow distinguish subtypes of pediatric acute lympoblastic leukemia. Trans Oncol 2020; 13: 100800.
    12. Hoque M, Elmaghrabi YA, Kose M, Beevi SS et al. Annexin A6 improves anti-migratory and anti-invasive properties of tyrosine kinase inhibitors in EGFR overexpressing human squamous epithelial cells. The FEBS J 2020; 287: 2961-2978.
    13. Menesses-Salas E, Melero AG, Kanerva K, Murioz PB, Beevi SS et al. Annexin A6 modulates TBC1d15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells. Cell Mol Life Sci 2020; 77: 2839-2857.
    14. Panchal NK, Bhale R, Chowdary R, Verma VK, Beevi SS. PCR amplifiable DNA from breast disease FFPE section for mutational analysis. J Biomol Tech 2020; 31: 1.
    15. Beevi SS, Bhale A, Panchal N, Siddiqui SAW et al. In vitro healing efficacy of stem cell secretome and cord blood platelet lysate on a chronic wound model. Wound Prac Res 2019.
    16. Beevi SS, Tangudu NK, Verma VK, Kumar LD, Biodrug suppresses breast and colorectal cancer in murine model. Methods Protocols 2019; 245 – 263.
    17. Anbarasu K, Verma VK, Beevi SS, Reddy VS. Environmental impact on the onset of hypertension-induced end stage renal disese. Int J Environ Health Sci 2018; 28: 511 – 521.
    18. Kurapati K, Tapadia S, Rao M, Anbarasu K, Verma VK, Beevi SS. Efficacy of intra-articular injection of platelet rich plasma and hyaluronic acid in early knee osteoarthritis: Case series. Eur J Mol Clin Med 2018; 5: 30 – 36.
    19. Kurapati K, Kumar GVP, Anbarasu, K, Vaggu AK, Nanduri V, Beevi SS et al. Wound Med 2018; 20: 54-57.
    20. Grewal T, Hoque M, Conway JRW, Reverter M, Wahba M, Beevi SS, Timpson P, Enrich C, Rentero C. Annexin A6-A multifunctional scaffold in cell motility. Cell Adh Migr 2017;11: 288-304
    21. Chakravdhanula U, Anbarasu K, Verma VK, Beevi SS. Clinical efficacy of platelet rich plasma in combination with methotrexate in chronic plaque psoriatic patients. Dermatologic Therapy 2016; 29: 446-450.
    22. Tangudu NK, Verma VK, Clemons TD, Beevi SS, Hay T, Kumar LK, et al. RNA Interference using c-Myc-Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models. Molecular Cancer Therapeutics, 2015; 14: 1259-1269.
    23. Verma VK, Beevi SS, Debnath T, Chelluri LK et al. Signal regulatory protein alpha (SIRPA) and kinase domain receptor (KDR) are key expression markers in cardiac specific precursor selection from hADSCs. New Horizons in Translational Medicine, 2015; 2: 93-101.
    24. Verma VK, Kamaraju SR, Kancherala R, Beevi SS et al. Fluorescent magnetic iron oxide nano-particles for cardiac precursor cell selection from stromal vascular fraction and optimization for magnetic resonance imaging. International Journal of Nanomedicine 2015; 10: 711-726
    25. Verma VK*, Beevi SS*, Tabassum A, Kumaresan K, Kamaraju RS, Chelluri LK. In vitro assessment of cytotoxicity and labeling efficiency of 99mTc-HMPAO with stromal vascular fraction of adipose tissue. Nuclear Medicine and Biology, 2014; 41: 744-748.
    26. Beevi SS, Verma VK, Chelluri LK, Lakshmi K, Debnath T, Shalini U, Kancherla R, Kamaraju R. Dual labeling strategy of SPION for optical and MR imaging of stem cell trafficking. Cytotherapy 2013; 15: S48-S48.
    27. Beevi SS, Chelluri LK. Understanding “niche”: A new paradigm in the success of UCBT. LAP LAMBERT Academic Publishing 2013, ISBN: 3659328189.
    28. Beevi SS, Mangamoori LN, Gowda BB. Polyphenolics and antioxidant properties of Raphanussativus L. Natural Product Research 2012; 26: 557-563.
    29. Beevi SS, Mangamoori LN, Subathra M, Edula JR. Hexane Extract of Raphanussativus L. Roots Inhibits Cell Proliferation and Induces Apoptosis in Human Cancer. Plant Foods for Human Nutrition 2010; 65: 200-209.
    30. Beevi SS, Mangamoori LN, Reddy LV. Protective effect of Raphanussativus on H2O2 induced cytotoxicity and oxidative DNA Damage in Human lymphocytes. World Journal of Microbiology and Biotechnology 2010; 26: 1519-1525.
    31. Beevi SS, Mangamoori LN, Gowda BB. Polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of Raphanussativus L. Plant Foods for Human Nutrition 2010; 65: 8-17.
    32. Beevi SS, Mangamoori LN, Anabrolu N. Comparative activity against pathogenic bacteria of the root, stem, and leaf of Raphanussativus grown in India. World Journal of Microbiology and Biotechnology 2009; 25: 465-473.
    33. Beevi SS, Mangamoori LN, Dhand V, Siva Ramakrishna D. Isothiocyanate Profile and Selective Antibacterial Activity of Root, Stem, and Leaf Extracts Derived from Raphanussativus L. Foodborne Pathogens and Disease 2009; 6: 129-136.
    34. Rasheed MH*, Beevi SS*, Rajaraman R, Bose SJ. Alleviation of oxidative and nitrosative stress following curative resection in patient with oral cavity cancer. Journal of Surgical Oncology 2007; 96:194-199.
    35. Beevi SS, Rasheed MH, Geetha A. Evidence of oxidative and nitrosative stress in patients with cervical squamous cell carcinoma. ClinicaChimicaActa 2007; 375:119-123.
    36. Rasheed MH*, Beevi SS*, Geetha A. Enhanced lipid peroxidation and nitric oxideproducts with deranged antioxidant status in patients with head and neck squamous cell carcinoma. Oral Oncology 2007; 43:333-338.
    37. Beevi SS, Rasheed MH, Geetha A. Evaluation of oxidative stress and nitric oxide levels in patients with oral cancer. Japanese Journal of Clinical Oncology 2004; 34: 379-385.
    38. Subatra M, Santhakumar P, Narasu ML, Beevi SS, Lal SK. Evaluation of antibody response in mice against avian influenza A (H5N1) strain neuraminidase expressed in yeast Pichia pastoris. Journal of Bioscience 2014; 39: 443–451.
    39. Debnath T, Shalini PU, Beevi SS, Verma VK, Chelluri LK, Ratnakar KS. An approach towards the proliferation and differentiation of stem cells on chitosan based soluble polymer. Cytotherapy 2013; 15: S43–S43.
    40. Reddy LV, Kethavath M, Nakka M, Beevi SS, Mangamoori LN, Mukkanti K, Pal S. Design and Synthesis of Novel Cytotoxic Agents Based on Combined Framework of Quinoline and Nimesulide. Journal of Heterocyclic Chemistry 2012; 49: 80.
    41. Priya VP, Radhika K, Kumar SR, Gowda BB, Beevi SS, Devi PY, Rao SA. In vitro anticancer activity of aqueous and acetone extracts of Tridaxprocumbens leaf on PC3 cell lines. International Journal of Pharmacy & Pharmaceutical Sciences 2011; 3: 356–358.
    42. Chelluri LK, Kancherla R, Turlapati N, Vemuri S, Debnath T, Kumar MP, Beevi SS, Kamaraju RS. Improved differentiation protocol of rat bone marrow precursors to functional islet-like cells. Stem Cell Studies 2011; 1: e5.
    43. Reddy LV, Nallapti SB, Beevi SS, Mangamoori LN, Mukkanti K, Pal S. A green synthesis of N-(quinoline-3-ylmethylene) benzohydrazide derivatives and their cytotoxicity activities. Journal of Brazilian Chemical Society 2011; 22: 1742-1749.
    44. Nakka M, Begum MS, Varaprasad BFM, Reddy LV, Bhattacharya A, Helliwell M, Mukherjee AK, Beevi SS, Mangamoori LN, Mukkanti K, Pal S. Naproxen and ibuprofen-based acyl hydrazone derivatives: Synthesis, structure analysis and cytotoxicity studies. Journal of Chemical and Pharmaceutical Research 2010; 2: 393-409.
    45. Reddy LV, Suman A, Beevi SS, Mangamoori LN, Mukkanti K, Pal S. Design and synthesis of 1-aroyl-2-lidene hydrazines under conventional/microwave irradiation conditions and their cytotoxic activities. Journal of Brazilian Chemical Society 2010; 21: 98-104.

Conference Presentations :

  • Beevi SS, Verma VK, Panigrahi MK. Unlocking Hope: Exosome-Based Liquid Biopsy Revolution In Glioma. Oral Presentation. 4th SIGN Conference, Hyderabad, Inda, 5-7 January 2024.
  • Verma VK, Beevi SS, Panigrahi MK. Patient Derived Primary Culture-Based Prognostic Model to Predict Tumor Recurrence in Patients with Glioma. 4th SIGN Conference, Hyderabad, Inda, 5-7 January 2024.
  • Beevi SS, Hoque M, Wahba M, Rentero C, Enrich C, Grewal T. Annexin A6 recruits TBC1D15 to regulate Rab7-dependent delivery of late endosomal cholesterol required for cell migration. Poster presentation. 8th Garvan Signalling Symposium, Sydney, Australia, 31 Oct – 1 Nov 2016.
  • Grewal T, Meneses-Salas E, Garcia-Melero A, Hoque M, Wahba M, Beevi SS, Rentero C, Enrich C. Annexin A6 recruits TBC1D15 to regulate Rab7-dependent delivery of late endosomal cholesterol required for cell migration. Oral Presentation. Hunter Cell Biology Meeting, Hunter Valley, Australia, 3-7 April 2017.
  • Grewal T, Meneses-Salas E, Garcia-Melero A, Hoque M, Wahba M, Beevi SS, Rentero C, Enrich C. Annexin A6 recruits TBC1D15 to regulate Rab7-dependent delivery of late endosomal cholesterol for cell migration. Poster presentation. 2nd Australian Cancer and Metabolism Meeting, Melbourne, Australia, 15-17 May 2017.
  • Beevi SS, Verma VK, Uma C, Anand V. Clinical Grade Multi-Potent Stem Cells from Human Hair Follicle (HF-MSCs) – an Appealing Source for Future Therapeutic Applications. Oral presentation. 6th International Conference on Stem Cells and Cancer, Pune, India, 2-5 October 2015.
  • Beevi SS, Verma VK, Chelluri LK, Lakshmi K, Debnath T, Shalini U, Kancherla R, Kamaraju R. Dual labeling strategy of SPION for optical and MR imaging of stem cell trafficking. Oral Presentation. 19th ISCT Annual Meeting, Auckland, New Zealand, Auckland, 22-25 April 2013.
  • Debnath T, Shalini PU, Beevi SS, Verma VK, Chelluri LK, Ratnakar KS. An approach towards the proliferation and differentiation of stem cells on chitosan based soluble polymer. Poster Presentation. 19th ISCT Annual Meeting, Auckland, New Zealand, Auckland, 22-25 April 2013.
  • Beevi SS, Mangamoori LN. 4-methylthio-3-butenyl isothiocyanate (MTBITC) – active principle isolated from indigenous white Raphanus sativus. Poster Presentation. 13th Asian Symposium on Medicinal Plants, Spices and other Natural Products (ASOMPS XIII), IICT, Hyderabad, India, 3-6 November 2008.